Structural Biochemistry Lab  

51. Sahu, S., Kumar, L., Das, S., Gupta, D., Anand, R*., Ultrasensitive detection of aromatic water pollutants through protein immobilization driven organic electrochemical transistors Chemical Science. 2024, 15, 710. LINK

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50. Sahil, M., Singh, J., Sahu, S., Pal.K. S., Yadav, A., Anand, R.*, Modal, J.*, Identifying Selectivity Filters in Protein Biosensor for Ligand Screening JACS Au. 2023, 3 (10), 2800–2812. LINK

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49. Das, S., Sahu, S., Bandyopadyaya, R., Anand, R*., Porous silica nanospheres: a nanoplatform  towards protein immobilization and cogent design of biosensors for aromatic water pollutant detection Environmental Science Nano.  2023, (DOI: 10.1039/d3en00217a). LINK

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48. Singh, S., Anand, R*., Diverse strategies adopted by nature for regulating purine biosynthesis via fine-tuning of purine metabolic enzymes Current Opinion in Chemical Biology. 2023, 73, 102261. LINK

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47. Singh, J., Sahil, M., Ray, S., Dcosta, C., Panjikar, S., Krishnamoorthy, G., Mondal, J*., Anand, R*., Phenol sensing in nature is modulated via a conformational switch governed by dynamic allostery J. Biol Chem. 2022, 298 (10), 102399. LINK

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46. Singh, J., Anand, R*., Horowitz, A*., Cooperativity in ATP Hydrolysis by MopR Is Modulated by Its Signal Reception Domain and by Its Protein and Phenol Concentrations Journal of Bacteriology 2022, 204 (8):e0017922 LINK

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45. Bhujbalrao, R., Gavvala, K., Singh, R., Singh, J., Boudier, C., Chakrabarti, S., Patwari, GN*., Mély, Y*., Anand, R*., Identification of Allosteric Hotspots regulating the ribosomal RNA-binding by Antibiotic Resistance-Conferring Erm Methyltransferases J. Biol Chem. 2022, 298 (8):102208. LINK

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44. Singh, J., Raina, R., Vinothkumar, KR., Anand, R*., Decoding the Mechanism of Specific RNA Targeting by Ribosomal Methyltransferases ACS Chemical Biology 2022 17(4): 829–839. LINK

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43. Sahu, S., Roy, R., Anand, R*., Harnessing the Potential of Biological Recognition Elements for Water Pollution Monitoring ACS Sensors 2022, 7(3), 704–715. LINK

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42. Sharma, N., Singh, S., Tanwar, A.S, Mondal, J., Anand, R*., Mechanism of Coordinated Gating and Signal Transduction in Purine Biosynthetic Enzyme Formylglycinamidine Synthetase ACS Catalysis 2022, 12, XXX, 1930–1944. LINK

 

41. Singh, S., Anand, R*., Tunnel Architectures in Enzyme Systems that Transport Gaseous Substrates ACS Omega 2021, 6(49): 33274–33283. LINK

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40. Mostert, KJ., Sharma, N., van der Zwaag, M., Staats, R., Koekemoer, L., Anand, R., Sibon, OC., Strauss, Eric*., The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity ACS Chemical Biology 2021, 16(11): 2401-2414. LINK

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39. Sen, A., Gaded, V., Jayapal, P., Rajaraman, G.*, Anand, R*., Insights into the Dual Shuttle Catalytic Mechanism of Guanine Deaminase J. Phys. Chem. B. 2021, 125(31), 8814 - 8826. LINK

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38. Mariam, J., Ashoka, A, H., Gaded, V., Ali, Firoz., Malvi, H., Das, A.*, Anand, R*., Deciphering protein microenvironment by using a cysteine specific switch-ON fluorescent probe Organic & Biomolecular Chemistry 2021, 19: 5161-5168. LINK

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37. Singh, J., Gaded, V., Bitra, A., Anand, R*., Structure Guided Mutagenesis Reveals the Substrate Determinants of Guanine Deaminase J. Struct. Biol. 2021, 213(3): 107747. LINK

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36. Roy, R., Ray, S., Chowdhury, A.*, Anand, R*., Tunable Multiplexed Whole-Cell Biosensors as Environmental Diagnostics for ppb-Level Detection of Aromatic Pollutants ACS Sensors 2021, 6(5) :1933–1939. LINK

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35. Sharma, N., Ahalawat, N., Sandhu, P., Strauss, E., Mondal, J., Anand, R*., Role of allosteric switches and adaptor domains in long-distance cross-talk and transient tunnel formation Sci. Adv. 2020, 6: eaay7919. LINK

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34. Bhaskar, S., Steer, D.L., Anand, R., Panjikar, S., Structural basis for differentiation between two classes of thiolase: Degradative vs biosynthetic thiolase  J. Struct. Biol. 2020, X, p.100018. LINK

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33. Mariam, J., Krishnamoorthy, G., Anand, R*., Use of 6‐Methylisoxanthopterin, a Fluorescent Guanine Analog, to Probe Fob1‐Mediated Dynamics at the Stalling Fork Barrier DNA Sequences Chemistry–An Asian Journal  2019, 14(24):4760-4766. LINK

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32. Bhujbalrao, R., Anand, R*., Deciphering Determinants in Ribosomal Methyltransferases that Confer Antimicrobial Resistance  J. Am. Chem. Soc.  2019, 141 (4), 1425-1429. LINK

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31. Ray, S., Panjikar, S., Anand, R*., Design of Protein based Biosensors for Selective Detection of Benzene Group of Pollutants, ACS Sensors 2018, 3(9), 1632–1638. LINK

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30. Ray S., Senapati, T, Sahu, S; Bandyopadhyaya, R, Anand, R.*, Design of Ultrasensitive Protein Biosensor Strips for Selective Detection of Aromatic Contaminants in Environmental Wastewater, Analytical Chemistry 2018, 90 (15), 8960-8968. LINK

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29. Gaded V, Anand R.*, Nucleobase Deaminases as potential enzymes for new therapies, RSC Adv. 2018,8, 23567-23577. LINK

 

28. Biswas, A., Mariam, A., Kombrabail, M., Narayan,S.,Krishnamoorthy, G.,Anand, R.*, Site-Specific Fluorescence Dynamics To Probe Polar Arrest by Fob1 in Replication Fork Barrier Sequences, ACS Omega 2017, 2, 7389-7399. LINK

 

27. Ray, S., Maitra, A., Biswas, A., Panjikar, S., Mondal, J., Anand R.*, Functional Insights into the Mode of DNA and Ligand Binding of the TetR Family Regulator TylP from Streptomyces fradiae, J. Biol Chem. 2017, 292, 15301-15311. LINK

 

26. Gaded, V., Anand, R.*, Selective Deamination of Mutagens by a Mycobacterial Enzyme, J. Am. Chem. Soc. 2017. 139(31):10762-10768. LINK

 

25. Bhukya, H., Anand, R.*; TetR Regulators: A Structural and Functional Perspective, J Indian Inst Sci 2017 97: 245. LINK

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24. Bhukya, H., Jana, A.K., Sengupta, N., Anand, R.*, Structural and Dynamics Studies of the TetR Family Protein, CprB from Streptomyces coelicolor in complex with its Biological Operator Sequence,J. Struct. Biol. 2017; 198; 134–146. LINK

 

23.  Bitra, A., Sistla, S.,Mariam, J., Malvi, H., Anand, R.*, Rassf Proteins as Modulators of Mst1 Kinase Activity, Sci. Rep. 2017. LINK

 

22.  Ray, S.,  Panjikar, S., Anand, R.*, Structure Guided Design of Protein Biosensors for Phenolic Pollutants,  ACS Sensors 2017; 2(3):411-418. LINK

 

21.  Ray, S.,Gunzburg, M., Wilce, M., Panjikar, S., Anand, R.*, Structural Basis of Selective Aromatic Pollutant Sensing by the Effector Binding Domain of MopR, an NtrC Family Transcriptional Regulator, ACS Chemical Biology 2016; 11, 2357−2365. LINK

 

20. Biswas, A., Narayan, S.,  Kallianpur, M, Krishnamoorthy,G. Anand, R. Mode of DNA Binding with γ-utyrolactone Receptor Protein CprB from Streptomyces coelicolor revealed by Site-specific Fluorescence Dynamics, Biochimica et Biophysica Acta 2015; 1850(11), 2283-92. LINK

 

19. Tanwar, A.S, Sindhikara, D.J,Hirata, F, Anand, R.*, Determination of the formylglycinamide ribonucleotide amidotransferase ammonia pathway by combining 3D-RISM theory with experiment, ACS Chemical Biology 2015;10(3), 698-704. LINK

 

18. Biswas, A., Swarnkar, R. K., Hussain, B., Sahoo, S.K., Pradeepkumar, P.I., Patwari, G.N., Anand, R.*;Fluorescence Quenching Studies of γ-Butyrolactone Binding Protein (CprB) from Streptomyces coelicolor A3(2); J Phys Chem B. 2014; 118(34):10035-42. LINK

 

17. Bhukya, H., Bhujbalrao, R., Bitra, A., Anand, R.*; Structural and functional basis of transcriptional regulation by TetR family protein CprB from S. coelicolor A3(2); Nucleic Acids Res. 2014; 42(15):10122-33. LINK

 

16. Tanwar, A.S., Goyal, V.D., Choudhary, D., Panjikar, S., Anand, R.*; Importance of hydrophobic cavities in allosteric regulation of formylglycinamide synthetase: insight from xenon trapping and statistical coupling analysis; PLoS One 2013; 8(11):e77781. LINK

 

15. Kotha, S., Goyal, D., Bitra, A.,  Thota, N.,  Kruger, G., Anand, R.*;   Diversity oriented approach to triazole  based peptidiomimetics as mammalian sterile 20 kinase inhibitors. RSC Adv. 2013; 3, 24447-24454. LINK

 

14. Bitra, A., Biswas, A., Anand, R.*; Structural basis of the substrate specificity of cytidine deaminase superfamily Guanine deaminase; Biochemistry 2013;52(45):8106-14. LINK

 

13. Bitra, A., Hussain, B., Tanwar, A.S., Anand, R.*, Identification of Function and Mechanistic Insights of Guanine Deaminase from Nitrosomonas europaea: Role of the C-Terminal Loop in Catalysis. Biochemistry 2013; 52(20):3512-22. LINK

 

12. Tanwar, A.S., Morar, M., Panjikar, S., Anand, R.*, Formylglycinamide ribonucleotide amidotransferase from Salmonella typhimurium: role of ATP complexation and the glutaminase domain in catalytic coupling, Acta Crystallographica Section D. 2012;68:627-36. LINK

 

11. Anand, R., Pagano, N., Maksimoska, J., Wong, E., Diamond, S. L., Meggers, E., Marmorstein, R.; Development of a Potent and Specific Organoruthenium Mammalian Sterile 20 Kinase Inhibitor,  Journal of Medicinal Chemistry. 2008; 52(6):1602-11. LINK

 

10. Brent, M., Anand, R., Marmorstein, R.; Structural Basis for DNA Recognition by FoxO1 and its Regulation by Post-Translational Modification; Structure 2008; 16(9):1407-16. LINK

 

9. Anand, R., Kim, A., Brent, M., Marmorstein, R.; Biochemical Analysis of MST1 Kinase: Elucidation of a C-Terminal Regulatory Region. Biochemistry 2008; 42, (25); 6719-6726. LINK

 

8. Anand, R., Marmorstein, R; Structure and mechanism of lysine-specific demethylase enzymes. J Biol Chem. 2007; 282(49):35425-9. LINK

 

7. Morar, M., Anand, R., Stubbe, J., Ealick, S.E.; Complexed structures of formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima describe a novel ATP binding protein superfamily. Biochemistry 2006; 45(50):14880-95. LINK

 

6. Anand, R., Hoskins, A. A., Bennett, E. M., Sintchak,  M.D., Stubbe, J.,  Ealick, S.E.; A model for the Bacillus subtilis formylglycinamide ribonucleotide amidotransferase multiprotein complex. Biochemistry 2004; 43(32):10343-52. LINK

 

5. Anand, R., Hoskins, A.A., Stubbe, J., Ealick, S.E. Domain organization of Salmonella typhimurium formylglycinamide ribonucleotide amidotransferase revealed by X-ray crystallography. Biochemistry 2004; 43(32):10328-42. LINK

 

4. Hoskins, A.A., Anand, R., Ealick, S.E., Stubbe, J.; The formylglycinamide ribonucleotide amidotransferase complex from Bacillus subtilis: metabolite mediated complex formation. Biochemistry 2004; 43(32):10314-27. LINK

 

3. Anand, R., Kaminski, V.S., Ealick, E.; Structure of Purine 2'- Deoxyribosyltransferase, Substrate Complexes and the Ribosylated Intermediate at 1.75 Resolution. Biochemistry 2004; 43(9):2384-93. LINK

 

2. Bennett, E.M., Anand, R., Allan, P.W., Hassan, A.E., Hong, J.S., Levasseur, D.N.,  McPherson, D.T., Parker, W.B.,  Secrist III, J.A., Sorcher, E.J., Townes, T.M.,  Waud, W.R., Ealick, S.E.;  Designer Gene Therapy Using an Escherichia coli Purine Nucloside Phosphorylase/Prodrug System. Chemistry & Biology 2003; 10(12):1173-81. LINK

 

1. Anand, R., Dorrestein, P.C., Kinsland, C., Begley, T., Ealick, S.E.; Structure of Oxalate Decarboxylase from Bacillus Subtilis at 1.75 Resolution. Biochemistry 2002; 41(24):7659-69. LINK

 

Published Book Chapters

 

2. Sahu S., Anand R., Strategies for Development of Protein-Based Biosensors for Detecting Aromatic Xenobiotics in Water, The World Scientific Reference of Water Science 2022, (doi: 10.1142/9789811245770_0004). Link

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1. Mariam J., Anand R., Fluorescence Quenching studies of γ-butyrolactone-Binding Protein (CprB) from Streptomyces coelicolor A3(2), Quorum Sensing: Methods and Protocols, Methods in Molecular Biology 2018, 1673, 131-143. PDF

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Patents

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1. Gupta D., Anand R., Kumar L., Sahu S., Organic Electrochemical Transistor Based Biosensor For The Detection Of DNA Binding Proteins And Method Of Preparation Thereof, Patent Number: 431170, Date of Grant: 08.05.2023.