Structural Biochemistry Lab  

52. Sahu, S., Ramachandran, S., Bandyopadhyaya, R*., & Anand, R*., Biosensing of multiple aromatic xenobiotics in 

       water by in-house fabricated prototype device. Biosensors and Bioelectronics. 2024, 250, 116077. LINK

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51. Sahu, S., Kumar, L., Das, S., Gupta, D., Anand, R*., Ultrasensitive detection of aromatic water pollutants through

       protein immobilization driven organic electrochemical transistors. Chemical Science. 2024, 15, 710. LINK

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50. Sahil, M., Singh, J., Sahu, S., Pal.K. S., Yadav, A., Anand, R.*, Modal, J.*, Identifying Selectivity Filters in Protein

       Biosensor for Ligand Screening. JACS Au. 2023, 3 (10), 2800–2812. LINK

​​

49. Das, S., Sahu, S., Bandyopadyaya, R., Anand, R*., Porous silica nanospheres: a nanoplatform towards protein

       immobilization and cogent design of biosensors for aromatic water pollutant detection. Environmental Science

      Nano.  2023, (DOI: 10.1039/d3en00217a). LINK

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48. Singh, S., Anand, R*., Diverse strategies adopted by nature for regulating purine biosynthesis via fine-tuning of

       purine metabolic enzymes. Current Opinion in Chemical Biology. 2023, 73, 102261. LINK

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47. Singh, J., Sahil, M., Ray, S., Dcosta, C., Panjikar, S., Krishnamoorthy, G., Mondal, J*., Anand, R*., Phenol sensing in

       nature is modulated via a conformational switch governed by dynamic allostery. J. Biol Chem. 2022, 298 (10),

      102399. LINK

​

46. Singh, J., Anand, R*., Horowitz, A*., Cooperativity in ATP Hydrolysis by MopR Is Modulated by Its Signal

       Reception Domain and by Its Protein and Phenol Concentrations. Journal of Bacteriology 2022, 204 

       8):e0017922 LINK

​

45. Bhujbalrao, R., Gavvala, K., Singh, R., Singh, J., Boudier, C., Chakrabarti, S., Patwari, GN*., Mély, Y*., Anand, R*.,

       Identification of Allosteric Hotspots regulating the ribosomal RNA-binding by Antibiotic Resistance-Conferring

       Erm Methyltransferases. J. Biol Chem. 2022, 298 (8):102208. LINK

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44. Singh, J., Raina, R., Vinothkumar, KR., Anand, R*., Decoding the Mechanism of Specific RNA Targeting by

       Ribosomal Methyltransferases. ACS Chemical Biology 2022, 17(4): 829–839. LINK

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43. Sahu, S., Roy, R., Anand, R*., Harnessing the Potential of Biological Recognition Elements for Water Pollution

      Monitoring. ACS Sensors 2022, 7(3), 704–715. LINK

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42. Sharma, N., Singh, S., Tanwar, A.S, Mondal, J., Anand, R*., Mechanism of Coordinated Gating and Signal

       Transduction in Purine Biosynthetic Enzyme Formylglycinamidine Synthetase. ACS Catalysis 2022, 12, XXX,

      1930–1944. LINK

 

41. Singh, S., Anand, R*., Tunnel Architectures in Enzyme Systems that Transport Gaseous Substrates. ACS Omega

      2021, 6(49): 33274–33283. LINK

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40. Mostert, KJ., Sharma, N., van der Zwaag, M., Staats, R., Koekemoer, L., Anand, R., Sibon, OC., Strauss, Eric*., The

      Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity.

      ACS Chemical Biology 2021, 16(11): 2401-2414. LINK

​

39. Sen, A., Gaded, V., Jayapal, P., Rajaraman, G.*, Anand, R*., Insights into the Dual Shuttle Catalytic Mechanism of

      Guanine Deaminase. J. Phys. Chem. B. 2021, 125(31), 8814 - 8826. LINK

​

38. Mariam, J., Ashoka, A, H., Gaded, V., Ali, Firoz., Malvi, H., Das, A.*, Anand, R*., Deciphering protein

      microenvironment by using a cysteine specific switch-ON fluorescent probe. Organic & Biomolecular Chemistry

      2021, 19: 5161-5168. LINK

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37. Singh, J., Gaded, V., Bitra, A., Anand, R*., Structure Guided Mutagenesis Reveals the Substrate Determinants of

      Guanine Deaminase. J. Struct. Biol. 2021, 213(3): 107747. LINK

​

36. Roy, R., Ray, S., Chowdhury, A.*, Anand, R*., Tunable Multiplexed Whole-Cell Biosensors as Environmental

      Diagnostics for ppb-Level Detection of Aromatic Pollutants. ACS Sensors 2021, 6(5) :1933–1939. LINK

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35. Sharma, N., Ahalawat, N., Sandhu, P., Strauss, E., Mondal, J., Anand, R*., Role of allosteric switches and adaptor

      domains in long-distance cross-talk and transient tunnel formation. Sci. Adv. 2020, 6: eaay7919. LINK

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34. Bhaskar, S., Steer, D.L., Anand, R., Panjikar, S., Structural basis for differentiation between two classes of

      thiolase: Degradative vs biosynthetic thiolase.  J. Struct. Biol. 2020, X, p.100018. LINK

​

33. Mariam, J., Krishnamoorthy, G., Anand, R*., Use of 6‐Methylisoxanthopterin, a Fluorescent Guanine Analog, to

       Probe Fob1‐Mediated Dynamics at the Stalling Fork Barrier DNA Sequences Chemistry– An Asian Journal 

      2019, 14(24):4760-4766. LINK

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32. Bhujbalrao, R., Anand, R*., Deciphering Determinants in Ribosomal Methyltransferases that Confer Antimicrobial

       Resistance.  J. Am. Chem. Soc.  2019, 141 (4), 1425-1429. LINK

​

31. Ray, S., Panjikar, S., Anand, R*., Design of Protein based Biosensors for Selective Detection of Benzene Group of

       Pollutants, ACS Sensors 2018, 3(9), 1632–1638. LINK

​

30. Ray S., Senapati, T, Sahu, S; Bandyopadhyaya, R, Anand, R.*, Design of Ultrasensitive Protein Biosensor Strips for

      Selective Detection of Aromatic Contaminants in Environmental Wastewater. Analytical Chemistry 2018, 90

      (15), 8960-8968. LINK

​

29. Gaded V, Anand R.*, Nucleobase Deaminases as potential enzymes for new therapies. RSC Adv. 2018,8,

       23567-23577. LINK

 

28. Biswas, A., Mariam, A., Kombrabail, M., Narayan,S.,Krishnamoorthy, G., Anand, R.*, Site-Specific Fluorescence

      Dynamics To Probe Polar Arrest by Fob1 in Replication Fork Barrier Sequences. ACS Omega 2017, 2, 7389

      7399. LINK

 

27. Ray, S., Maitra, A., Biswas, A., Panjikar, S., Mondal, J., Anand R.*, Functional Insights into the Mode of DNA and

       Ligand Binding of the TetR Family Regulator TylP from Streptomyces fradiae. J. Biol Chem. 2017, 292, 15301

      15311. LINK

 

26. Gaded, V., Anand, R.*, Selective Deamination of Mutagens by a Mycobacterial Enzyme. J. Am. Chem. Soc. 2017.

      139(31):10762-10768. LINK

 

25. Bhukya, H., Anand, R.*; TetR Regulators: A Structural and Functional Perspective. J Indian Inst Sci 2017. 97:

       245. LINK

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24. Bhukya, H., Jana, A.K., Sengupta, N., Anand, R.*, Structural and Dynamics Studies of the TetR Family Protein,

      CprB from Streptomyces coelicolor in complex with its Biological Operator Sequence. J. Struct. Biol. 2017; 198;

      134–146. LINK

 

23.  Bitra, A., Sistla, S.,Mariam, J., Malvi, H., Anand, R.*, Rassf Proteins as Modulators of Mst1 Kinase Activity. Sci.

       Rep. 2017. LINK

 

22.  Ray, S.,  Panjikar, S., Anand, R.*, Structure Guided Design of Protein Biosensors for Phenolic Pollutants. ACS

       Sensors 2017; 2(3):411-418. LINK

 

21.  Ray, S.,Gunzburg, M., Wilce, M., Panjikar, S., Anand, R.*, Structural Basis of Selective Aromatic Pollutant Sensing

        by the Effector Binding Domain of MopR, an NtrC Family Transcriptional Regulator. ACS Chemical Biology

       2016; 11, 2357−2365. LINK

 

20. Biswas, A., Narayan, S.,  Kallianpur, M, Krishnamoorthy,G. Anand, R*. Mode of DNA Binding with γ-utyrolactone

       Receptor Protein CprB from Streptomyces coelicolor revealed by Site-specific Fluorescence Dynamics.

      Biochimica et Biophysica Acta 2015; 1850(11), 2283-92. LINK

 

19. Tanwar, A.S, Sindhikara, D.J,Hirata, F, Anand, R.*, Determination of the formylglycinamide ribonucleotide

       amidotransferase ammonia pathway by combining 3D-RISM theory with experiment. ACS Chemical Biology

      2015;10(3), 698-704. LINK

 

18. Biswas, A., Swarnkar, R. K., Hussain, B., Sahoo, S.K., Pradeepkumar, P.I., Patwari, G.N., Anand, R.*; Fluorescence

      Quenching Studies of γ-Butyrolactone Binding Protein (CprB) from Streptomyces coelicolor A3(2); J Phys Chem

      B. 2014; 118(34):10035-42. LINK

 

17. Bhukya, H., Bhujbalrao, R., Bitra, A., Anand, R.*; Structural and functional basis of transcriptional regulation by

       TetR family protein CprB from S. coelicolor A3(2); Nucleic Acids Res. 2014; 42(15):10122-33. LINK

 

16. Tanwar, A.S., Goyal, V.D., Choudhary, D., Panjikar, S., Anand, R.*; Importance of hydrophobic cavities in allosteric

       regulation of formylglycinamide synthetase: insight from xenon trapping and statistical coupling analysis; PLoS

      One 2013; 8(11):e77781. LINK

 

15. Kotha, S., Goyal, D., Bitra, A.,  Thota, N.,  Kruger, G., Anand, R.*;   Diversity oriented approach to triazole  based

       peptidiomimetics as mammalian sterile 20 kinase inhibitors. RSC Adv. 2013; 3, 24447-24454. LINK

 

14. Bitra, A., Biswas, A., Anand, R.*; Structural basis of the substrate specificity of cytidine deaminase superfamily

      Guanine deaminase; Biochemistry 2013; 52(45):8106-14. LINK

 

13. Bitra, A., Hussain, B., Tanwar, A.S., Anand, R.*, Identification of Function and Mechanistic Insights of Guanine

      Deaminase from Nitrosomonas europaea: Role of the C-Terminal Loop in Catalysis. Biochemistry 2013;

      52(20):3512-22. LINK

 

12. Tanwar, A.S., Morar, M., Panjikar, S., Anand, R.*, Formylglycinamide ribonucleotide amidotransferase from

       Salmonella typhimurium: role of ATP complexation and the glutaminase domain in catalytic coupling, Acta

      Crystallographica Section D. 2012; 68:627-36. LINK

 

11. Anand, R., Pagano, N., Maksimoska, J., Wong, E., Diamond, S. L., Meggers, E., Marmorstein, R.; Development of a

       Potent and Specific Organoruthenium Mammalian Sterile 20 Kinase Inhibitor,  Journal of Medicinal Chemistry.

      2008; 52(6):1602-11. LINK

 

10. Brent, M., Anand, R., Marmorstein, R.; Structural Basis for DNA Recognition by FoxO1 and its Regulation by

       Post-Translational Modification; Structure 2008; 16(9):1407-16. LINK

 

  9. Anand, R., Kim, A., Brent, M., Marmorstein, R.; Biochemical Analysis of MST1 Kinase: Elucidation of a C-

      Terminal Regulatory Region. Biochemistry 2008; 42, (25); 6719-6726. LINK

 

  8. Anand, R., Marmorstein, R; Structure and mechanism of lysine-specific demethylase enzymes. J Biol Chem.

      2007; 282(49):35425-9. LINK

 

  7. Morar, M., Anand, R., Stubbe, J., Ealick, S.E.; Complexed structures of formylglycinamide ribonucleotide

      amidotransferase from Thermotoga maritima describe a novel ATP binding protein superfamily. Biochemistry

      2006; 45(50):14880-95. LINK

 

  6. Anand, R., Hoskins, A. A., Bennett, E. M., Sintchak,  M.D., Stubbe, J.,  Ealick, S.E.; A model for the Bacillus subtilis

      formylglycinamide ribonucleotide amidotransferase multiprotein complex. Biochemistry 2004; 43(32):10343

      52. LINK

 

  5. Anand, R., Hoskins, A.A., Stubbe, J., Ealick, S.E. Domain organization of Salmonella Typhimurium

      formylglycinamide ribonucleotide amidotransferase revealed by X-ray crystallography. Biochemistry 2004;

      43(32):10328-42. LINK

​

  4.  Hoskins, A.A., Anand, R., Ealick, S.E., Stubbe, J.; The formylglycinamide ribonucleotide aminotransferase

       complex from Bacillus subtilis: metabolite mediated complex formation. Biochemistry 2004; 43(32):10314

       27. LINK

 

  3. Anand, R., Kaminski, V.S., Ealick, E.; Structure of Purine 2'- Deoxyribosyltransferase, Substrate Complexes and

      the Ribosylated Intermediate at 1.75 Resolution. Biochemistry 2004; 43(9):2384-93. LINK

 

  2. Bennett, E.M., Anand, R., Allan, P.W., Hassan, A.E., Hong, J.S., Levasseur, D.N.,  McPherson, D.T., Parker, W.B., 

      Secrist III, J.A., Sorcher, E.J., Townes, T.M.,  Waud, W.R., Ealick, S.E.;  Designer Gene Therapy Using an Escherichia

      coli Purine Nucloside Phosphorylase/Prodrug System. Chemistry & Biology 2003; 10(12):1173-81. LINK

 

  1. Anand, R., Dorrestein, P.C., Kinsland, C., Begley, T., Ealick, S.E.; Structure of Oxalate Decarboxylase from Bacillus

      Subtilis at 1.75 Resolution. Biochemistry 2002; 41(24):7659-69. LINK​​​